Matthews Correlation Coefficient: when to use it and when to … Web08.04.2020 · F1 score ignores the count of True Negatives. In contrast, MCC kindly extends its care to all four entries of the confusion matrix. Davide Chicco, the author of Ten quick tips for machine learning in computational biology, commented that MCC “is high only if your classifier is doing well on both the negative and the positive elements.”